Best recognized as one of seven living people born with Tetra-amelia syndrome, a disorder characterized by the absence of all four limbs. She was named Young Person of the Year and appears in the 2013 documentary No Limbs No Limits.
She first gained attention for skipping school to confront Taoiseach Enda Kenny about his proposed plan to reduce disability funding during his election. Though he told her he would not cut funding, upon his election, he did slash the disability budget.
In April 2012, she spoke before the United Nations to address the use of technology and challenge the UN to create technology to help disabled people such as herself.
Her brother Steven produced the documentary about her life called No Limbs No Limits.
Both she and boxer Katie Taylor were named People of the Year for 2012.