Famous for her roles in Spanish television series such as The Boarding School, Central Hospital and Los Elegidos. She is also notable for her Goya Award-winning performance in the 2012 feature film Blancanieves. She starred in the film Despite Everything in 2019.
Before beginning her acting career, she trained as an artistic gymnast; performed at the Theatre of Madrid; and entered the Autonomous University of Madrid as a psychology major.
Her performance in a 2013 stage production of the musical La Llamada (The Call) earned her the prestigious Premios Fotogramas de Plata.
Her full name is Macarena García de la Camacha Gutiérrez-Ambrossi. Born and raised in Madrid, Spain, she is the sister of fellow actor Javier Ambrossi. Her father is Javier García Camacha.
She is a contemporary of fellow Spanish actress Alba Rico.