In 2008, he married singer and actress Mariah Carey. The couple welcomed twins named Moroccan and Monroe in 2011 and in 2014, he and Carey separated. In 2017, his second son Golden Cannon was born to his ex-girlfriend Brittany Bell. Their second child together, a daughter named Powerful Queen, arrived in December 2020. He welcomed twins with Abby De La Rosa in June 2021. His seventh child Zen was born on June 23, 2021; model Alyssa Scott is the mother. Zen passed away towards the end of 2021. He welcomed a son with Bre Tiesi in July 2022. In August 2022, Brittany Bell and Cannon announced that they were expecting their second child together. The couple welcomed a daughter in September 2022. In the same month, he also welcomed Onyx Ice Cole with Lanisha Cole. In November 2022, Cannon announced that he was expecting a second child with Alyssa Scott. In December 2022, Cannon and Scott welcomed a daughter named Halo Marie, his 12th child.
In 2003 he released the hit single "Gigolo" in collaboration with R. Kelly.