Starred as Laverne DeFazio in the sitcom Laverne & Shirley, then went on to become a director sf such films as Awakenings, A League of Their Own and Big, starring Tom Hanks. With Big, she became the first female director to have a film gross over $100 million.
She met Michael Henry in college and they were married in 1961. She later married Rob Reiner on April 10, 1971. They divorced in 1981. She and Rob had a daughter named Tracy Reiner who became an actress.
In 2009, she directed Jim Belushi in a pair of episodes of the sitcom According to Jim.