Born Reginald Noble, he is a Grammy-nominated rapper and actor who is best known for his collaborations with Method Man. He starred in the 2001 stoner comedy How High and the 2004 comedy/horror Seed of Chucky and briefly had his own sitcom on Fox entitled Method & Red.
He attended Montclair State University in New Jersey.
He was in the first season of Chappelle's Show in a sketch where he sells his own brand of bathroom products.
His grandmother is Korean, and his cousin is rapper Tame One. He grew up with a sister named Rosalyn who is a rapper herself. He has five children.
He appeared alongside Jamie Foxx in an episode of The Jamie Foxx Show.