In the year of Seraphina's birth, two of her mother's films (Ghosts of Girlfriends Past and The Invention of Lying) were released, and three of her father's movies (He's Just Not That Into You, State of Play, and Extract) debuted.
Her maternal grandparents are Patricia Ann English and William John Garner, and her paternal grandparents are Chris Boldt and Timothy Byers Affleck. She is the niece of Melissa Lynn Garner Wylie, Susannah Kay Garner Carpenter, and Casey Affleck. In 2015, her parents announced they were divorcing.
Alias actor Victor Garber was the officiant at Seraphina's parents' 2005 wedding ceremony.