Jackie Harris on Roseanne and Carolyn Bigsby on 'Desperate Housewives.
While studying in college, she befriended fellow actors John Malkovich, Gleanne Headley, Gary Sinise, and more.
She played Sheldon's mom in several episodes of The Big Bang Theory.
Married Jeff Perry in 1983; the couple had one daughter and later divorced.
She voiced the part of Andy's mom in the Toy Story movies, with Tom Hanks and Tim Allen.