She worked for the McKinsey & Company consulting firm as well as Avenue Capital Group in the early 2000s.
She married Marc Mezvinsky in 2010 and, on September 27, 2014, the couple had their first child, a daughter named Charlotte. They welcomed a son named Aidan in June 2016. In January 2019, they announced they were expecting their third child together.
Her father Bill Clinton served as President of the United States from 1993 to 2001.