2005 National League Cy Young Award winner who helped lead the St. Louis Cardinals to World Series titles in 2006 and 2011.
He pitched in the Pioneer League in 1994, where he had the league's third-lowest ERA.
He was named National League Comeback Player of the Year in 2009 after a miraculous return from Tommy John surgery.
He had a son, Sam, and daughter, Ava, with his wife Alyson.
He won the World Series twice alongside superstar hitter Albert Pujols.