She was born Laurence Wachowski and began undergoing gender transitioning in the early 2000s. Her full transition was revealed in 2008.
She and Lilly created the Netflix original series Sense8. She received the Human Rights Campaign's Visibility Award.
She was born in Chicago to a mother, Lynne, who was a nurse and painter and father, Ron, who was a businessman. In addition to Lilly, she has two other sisters named Julie and Lauren. Her uncle is actor Laurence Luckinbill.