Became a pop star after her debut album Yours Truly achieved widespread success in 2013. She then followed up with the similarly popular album My Everything, which featured the hit singles "Break Free" and "Problem." She first gained fame as an actress, portraying Cat Valentine on the Nickelodeon series Victorious as well as on the show's spin-off Sam and Cat.
She began her career as a soloist with various symphonies, such as the South Florida Philharmonic. She made her acting debut as Charlotte in the Broadway musical 13 in 2008.
She voiced the character Diaspro in seasons 3 through 5 of the Nickelodeon series Winx Club and appeared in the 2013 TV movie Swindle. In 2015, she began playing Chanel #2 on the Fox horror/comedy series Scream Queens.
Her parents are named Joan and Edward, and her older brother Frankie Grande starred on Big Brother 16. She was very close with her grandfather Frank who passed away in 2014. She began dating Nathan Sykes, a member of The Wanted, in September 2013. The couple separated a few months later. In 2014, she had a fairly public relationship with web video star Jai Brooks, then she dated rapper Big Sean until April 2015. She dated her backup dancer Ricky Alvarez for several months in 2015 and 2016 before beginning a relationship with rapper Mac Miller in August 2016.
In 2011, she appeared alongside Miranda Cosgrove in an episode of iCarly titled "iParty with Victorious."