Perhaps most famous for her Drama Desk Award-winning and Tony Award-nominated performance as Phoebe D'Ysquith in the original Broadway production of A Gentleman's Guide to Love and Murder, Worsham is also known for her portrayal of Cunegonde in the New York City Opera's 2008 production of Candide.
After earning a bachelor's degree in Spanish from Yale University, she performed in the debut national tour of the musical comedy The 25th Annual Putnam County Spelling Bee.
She co-founded a theatre company called The Coterie.
She and her brother Parker grew up in Austin, Texas as the children of Belinda and Dennis Worsham. She later settled in New York City, where she formed the rock band Sky-Pony with her musician husband Kyle Jarrow.
She and Heather Lind were both in the cast of the 2012 feature film The Last Day of August.