He rose to fame as the bassist of the rock bands Talk Show and Army of Anyone.
He began his career as the bassist for Stone Temple Pilots.
He produced the 2010 album Stone Temple Pilots and the 2003 Alien Ant Farm album TruANT.
His brother, Dean DeLeo, played guitar for Stone Temple Pilots.
He cited The Who bassist John Entwistle as one of his musical influences.