Best known for playing the title role of Dr. Gregory House on the hit TV series House M.D. He was cast in the 2015 feature Tomorrowland.
He became involved with stars Emma Thompson and Stephen Fry, during his time in Cambridge Footlights.
Despite his dead-on American accent, he was actually born in England.
He married Jo Green in 1989.
He starred with Kate Winslet in the 1995 version of Sense and Sensibility.