Best known for playing the title role of Dr. Gregory House on the hit TV series House M.D. He was cast in the 2015 feature Tomorrowland. In 2019, he began starring in Hulu's Catch-22. He previously was in the BBC miniseries The Night Manager.
Despite his heavy American accent, he was actually born in England.
He married Jo Green in 1989. They have a daughter and two sons together.