Younger sister of Kourtney and Kim Kardashian who gained fame on the reality television program Keeping Up with the Kardashians. She has also starred in various spin-offs including Kocktails with Khloé, Revenge Body with Khloé Kardashian and Kourtney & Khloé Take the Hamptons.
She dropped out of high school, but continued her education as a home school student.
She married NBA star Lamar Odom in September 2009 after meeting him at one of Metta World Peace's parties. During a hiatus with Odom, she dated rapper French Montana and NBA star James Harden. In 2016, she began a relationship with Tristan Thompson and the pair welcomed a baby girl named True on April 12, 2018. She and Tristan Thompson separated in early 2019.