She graduated from the University of Arizona with a theatre arts degree and Spanish minor.
She first appeared on TV on the 2005 E! reality series Filthy Rich: Cattle Drive.
She had her third child, a son named Reign Aston Disick, with Scott Disick in December 2014, after previously having a son named Mason Dash Disick and a daughter named Penelope Scotland Disick. She began her on-and-off relationship with Scott in 2006. From 2017 to 2018, she dated model Younes Bendjima.
She is one of the three Kardashian sisters, and the daughter of late defense attorney Robert Kardashian.