While at New York University, she acted in TV commercials.
She married Dennis Quaid in 1991, and the couple welcomed their son Jack in 1992. They divorced in 2001. She adopted a daughter named Daisy from China in 2006. She got engaged to John Mellencamp in 2018, but the two called the wedding off in October 2019.
She starred in Kate & Leopold with Hugh Jackman.