He shared the Good Will Hunting Oscar with co-star and co-writer Ben Affleck. His other films include The Bourne series, the Ocean's trilogy, We Bought a Zoo, The Martian, and The Talented Mr. Ripley.
Growing up with Ben Affleck, who is his tenth cousin, once removed, helped shape his dream of becoming an actor. He dropped out of Harvard University, where he was majoring in English, to pursue a career in acting.
He played the role of Private Ryan in Steven Spielberg's 1998 film Saving Private Ryan.
His father Kent worked as a stockbroker and his mother Nancy worked as a professor for early childhood education. He dated actress Winona Ryder from 1997 to 2000. He married Luciana Barroso in 2005 and he has four daughters named Alexia, Stella, Gia and Isabella.
He co-starred with Leonardo DiCaprio in the 2006 thriller, The Departed.