Actress who received Academy Award nominations for her roles in the films Being John Malkovich and Capote. Other film credits include The 40-Year-Old Virgin, Into the Wild, Living in Oblivion, Percy Jackson & the Olympians: The Lightning Thief and Synecdoche, New York. In 2018, she began starring in Showtime's Kidding.
She enrolled in her first theater course because she was unable to get into a photography course.
She worked as a manager at a New York City McDonald's after graduating from college.
She was married to Dermot Mulroney from 1990 until 2007.
She played the love interest of Steve Carell's character in the 2005 comedy The 40-Year-Old Virgin.