Actress best known for her roles as Jackie Harris on Roseanne and as Carolyn Bigsby on Desperate Housewives. She received acclaim for her role in the 2017 film Lady Bird. She is also a stage actress and has received four Tony Award nominations for her work.
While studying in college, she befriended fellow actors John Malkovich, Gleanne Headley, Gary Sinise, and more.
She played Sheldon's mom in several episodes of The Big Bang Theory.
She married Jeff Perry in 1983. The couple had a daughter named Zoe and divorced in 1992. She was then married to Matt Roth from 1993 to 2014.
She voiced the part of Andy's mom in the Toy Story movies with Tom Hanks and Tim Allen.