Actor known for playing the role of Dr. Mark "McSteamy" Sloan on the hit television show Grey's Anatomy, he was cast as Tom Chandler on The Last Ship. He also appeared in Burlesque as Marcus Gerber.
He decided to pursue acting as a career after appearing in his school's production of Arthur Miller's All My Sons.
He played Jason Dean on Charmed and Multiple Man in X-Men: The Last Stand.
He married Rebecca Gayheart in 2004. The couple welcomed their first daughter in 2010 and their second daughter in 2011 before divorcing in 2018.
He starred with Patrick Dempsey on Grey's Anatomy.